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When we are diagnosed with diabetes our bodies produce insufficient insulin, a very important hormone that helps take the glucose (sugar) we get from food and use it as energy.

The cells that produce insulin are our beta cells, they do not reproduce easily, they actually get exhausted over time, die out and lose their function, and we then end up with diabetes. Beta cell growth is controlled by a protein called menin. If there would be no menin around, beta cells could freely turnover, supporting the notion that the inhibition of menin potentially could lead to the reactivation, regeneration and even protection of beta cells.

BMF-219 was designed to specifically target menin and inhibit/degrade its function for a short period of time, so beta cells can potentially grow again, allowing them to rebalance and effectively restore our natural insulin production – to control and normalize sugar levels again.

The Biomea Fusion Research Team is currently evaluating in a clinical study (COVALENT-111) a new way to help your body potentially restore beta cells, so you can again make the insulin you need – naturally.