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Menin and Diabetes Literature

Diabetes and Beta-Cell Function

  • Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science. 2005 Jan 21;307(5708):380-4. doi: 10.1126/science.1104345. PMID: 15662003.
  • Usman TO, Chhetri G, Yeh H, Dong HH. Beta-cell compensation and gestational diabetes. J Biol Chem. 2023 Oct 29;299(12):105405. doi: 10.1016/j.jbc.2023.105405. PMCID: PMC10694657.
  • Saisho Y. Postprandial C-Peptide to Glucose Ratio as a Marker of β Cell Function: Implication for the Management of Type 2 Diabetes. Int J Mol Sci. 2016 May 17;17(5):744. doi: 10.3390/ijms17050744. PMID: 27196896; PMCID: PMC4881566.

Beta-Cell Proliferation

  • Van Assche FA, Aerts L, De Prins F. A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol. 1978 Nov;85(11):818-20. doi: 10.1111/j.1471-0528.1978.tb15835.x. PMID: 363135.
  • Linnemann AK, Baan M, Davis DB. Pancreatic β-cell proliferation in obesity. Adv Nutr. 2014 May 14;5(3):278-88. doi: 10.3945/an.113.005488. PMID: 24829474; PMCID: PMC4013180.
  • Cao, Y., Feng, Z., He, X., Zhang, X., Xing, B., Wu, Y., Hojnacki, T., Katona, B. W., Ma, J., Zhan, X., & Hua, X. (2022). Prolactin-regulated Pbk is involved in pregnancy-induced β-cell proliferation in mice. Journal of Endocrinology, 252(2), 107-123. https://doi.org/10.1530/JOE-21-0114
  • Shrivastava V, Lee M, Lee D, Pretorius M, Radford B, Makkar G, Huang C. Beta cell adaptation to pregnancy requires prolactin action on both beta and non-beta cells. Sci Rep. 2021 May 14;11(1):10372. doi: 10.1038/s41598-021-89745-9. PMID: 33990661; PMCID: PMC8121891.
  • Huang C. (2013). Wild-type offspring of heterozygous prolactin receptor-null female mice have maladaptive β-cell responses during pregnancy. The Journal of physiology, 591(5), 1325–1338. https://doi.org/10.1113/jphysiol.2012.244830
  • Salazar-Petres, E. R., & Sferruzzi-Perri, A. N. (2022). Pregnancy-induced changes in β-cell function: what are the key players?. The Journal of physiology, 600(5), 1089–1117. https://doi.org/10.1113/JP281082

Menin and Beta-Cell Proliferation

  • Karnik, S. K., Chen, H., McLean, G. W., Heit, J. J., Gu, X., Zhang, A. Y., Fontaine, M., Yen, M. H., & Kim, S. K. (2007). Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science (New York, N.Y.), 318(5851), 806–809. https://doi.org/10.1126/science.1146812
    Hughes, E., & Huang, C. (2011). Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation. Endocrinology, 152(3), 847–855. https://doi.org/10.1210/en.2010-1250
  • Ma, J., Xing, B., Cao, Y., He, X., Bennett, K. E., Tong, C., An, C., Hojnacki, T., Feng, Z., Deng, S., Ling, S., Xie, G., Wu, Y., Ren, Y., Yu, M., Katona, B. W., Li, H., Naji, A., & Hua, X. (2021). Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation. EMBO molecular medicine, 13(5), e13524. https://doi.org/10.15252/emmm.202013524
    Zhang, H., Li, W., Wang, Q., Wang, X., Li, F., Zhang, C., Wu, L., Long, H., Liu, Y., Li, X., Luo, M., Li, G., & Ning, G. (2012). Glucose-mediated repression of menin promotes pancreatic β-cell proliferation. Endocrinology, 153(2), 602–611. https://doi.org/10.1210/en.2011-1460
  • Yang, Y., Gurung, B., Wu, T., Wang, H., Stoffers, D. A., & Hua, X. (2010). Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20358–20363. https://doi.org/10.1073/pnas.1012257107
  • Karnik, S. K., Hughes, C. M., Gu, X., Rozenblatt-Rosen, O., McLean, G. W., Xiong, Y., Meyerson, M., & Kim, S. K. (2005). Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proceedings of the National Academy of Sciences of the United States of America, 102(41), 14659–14664. https://doi.org/10.1073/pnas.0503484102
  • Yang Y, Wang H, Hua X. Deletion of the Men1 gene prevents streptozotocin-induced hyperglycemia in mice. Exp Diabetes Res. 2010;2010:876701. doi: 10.1155/2010/876701. Epub 2011 Jan 17. PMID: 21318185; PMCID: PMC3034935